International MRIlab Module I - A Journey From The Basics To Advanced Methodologies of MRI

Siena, Italy

from 17/02/2022 until 18/02/2022













Event format

























To register for this event, contact



Registration fee







- Module I: Siena, 17-18 Feb 2022

- Intermediary Webinar: 21 Apr 2022

- Module II: Barcelona, 7-9 Jun 2022


Modules I & II are mandatory to the completion of the course and are included in the registration fee of €600. 

Early Bird Special20% discount on registration fee for those registering by October 31st 2021.


All applications will be reviewed by the scientific committee members who will select the best candidates according to their profiles. Successful candidates will participate in both Module I & II.

The following requirements are needed to apply:

  • An abbreviated curriculum vitae of the applicant including bibliography of any relevant publication
  • An applicant’s letter of intent
  • A letter of reference from the applicant’s mentor
  • Registration fee

The registration fee includes both Modules I & II, as well as : 

  • Intermediary Webinar
  • Online tutorials
  • Live interventions
  • Coffee breaks and lunch
  • Educational materials
  • Certificate of attendance




































This collaborative EXCEMED multi-format programme, includes a series of international MRILab Workshops designed for young neurologists/ neuroradiologists or other professionals with a particular interest in quantitative MRI applied to research in Multiple Sclerosis.






In demyelinating and neurodegenerative disorders such as multiple sclerosis (MS), magnetic resonance imaging (MRI) supports diagnostic and therapeutic decisions, assesses prognosis, and improves understanding of the disease. Standardisation and optimisation of MRI acquisition protocols and analysis are therefore critical, both in clinical and research settings. Quantitative methods assessing lesions and atrophy are far less subjective for measuring disease burden in MS, compared with visual inspection, and are moving from research into clinical settings. Structural damage is predictive of motor and cognitive disability and needs to be accurately quantified, also in order to measure response to treatment. Several methods for imaging post-processing have been developed over time with different strengths, limits and scopes. However, whereas quantitative MRI measures have been extensively used in clinical studies and as endpoints in clinical trials, their introduction in the clinical setting has been difficult due to a number of methodological issues.

EXCEMED together with the team of the University of Siena - Experimental Neurology Unit, Department of Medicine, Surgery and Neurosciences - and with the Vall d’Hebron University Hospital in Barcelona - Section of Neuroradiology and MRI Unit, Department of Radiology designed the MRILab - have developed an international training period for young neurologists and neuroradiologists particularly interested in quantitative neuroimaging applied to research in demyelinating and neurodegenerative disorders. 





Learning objectives



Through a series of different educational formats - both live and online - the MRI-Lab, facing basic and advanced methodological key aspects related to the use of quantitative measures of lesions and atrophy, aims to achieve the following learning objectives:

  • Illustrate the main issues in the standardisation and optimisation of MRI acquisition protocols
  • Describe how to facilitate image post-processing
  • Discuss strengths and limits of currently used software packages for image quantification
  • Deliver full analysis of lesion burden and atrophy in MRI samples.


Pre-Event Tutorials

These preparatory tutorials provide an overview of the course for the modules, focusing on the main goals that attendees will achieve through their learning journey in the field of quantitative MRI. The video scribing format facilitates the understanding of the entire learning path, translating scientific concepts into graphic maps. The tutorials will: 

  • Define the importance of quantitative imaging in the evaluation of structural damage in MS
  • Explain the main advancements and pitfalls in this field and how to approach quantitative MRI in a critical way


Post Event Tutorials

The post-course tutorials aim to summarise the main topics delivered in the modules. It will provide attendees with tips and practical exercises to help them develop original research projects building on the information gathered during the course. The tutorials will:

  • Simplify complex concepts into manageable information
  • Efficiently translate the theory of quantitative MRI into working knowledge



In order to get a full benefit of attending the course, attendants need to have some knowledge in the analysis of brain and spinal cord MRI studies, and ensure that the basic tools required to perform basic quantitative analysis of brain and spinal cord MRI studies will be available at their host institution (or on a personal laptop). Instructions on how to install the tools will be given on module I, and thy should be installed before the module II. Requirements: MIPAV (, Matlab (basic license), Statistical Parametric Mapping (; free software but needs Matlab to run), FSL ( and Spinal Cord Toolbox (, which run over a Linux/Unix system (in case you work with PCs, a Virtual Machine should be installed).





Accreditation details



An application for CME accreditation has been made to the European Accreditation Council for Continuing Medical Education (EACCME®) 





















































































































ESNR Members benefit from a 15% reduction. In order to benefit from this reduction please send your 2021 Membership Payment Receipt when registering to the course. 

































































Map data ©2021








Terms of Use
















Scientific programme



DAY 1 - Thursday, 17 February 2022 

14.00           Opening and Welcome 

                    N. De Stefano (Italy) - À. Rovira (Spain) 

14.15  L1:    MRI acquisition protocols and characteristics of MRI sequences for brain lesion load and volume assessment

                    À. Rovira (Spain) 

14:35  L2:    Clinical relevance of white matter lesions 

                    N. De Stefano (Italy)

14.55           Q&A

15.15          Break 

15.25  L3:    Pathology of grey matter in multiple sclerosis

                    M. Schoonheim (The Netherlands)

15.45  L4:    Clinical relevance of grey matter lesions

                    N. De Stefano (Italy)

16.05  L5:    MRI acquisition protocols for grey matter lesions assessment

                    À. Rovira (Spain) 

16.25          Q&A

16.45           Wrap-up day 1

17.00          End day 1 


DAY 2 - Friday, 18 February 2022 

09.00  L6:     MRI markers of disease progression

                     À. Rovira (Spain) 

09.20  L7:     Clinical relevance of brain and spinal cord atrophy

                     N. De Stefano (Italy)

09:40  L8:     Artificial intelligence for creating predictive models in multiple sclerosis

                     M. de Bruijne (The Netherlands)

10.00           Q&A

10.20           Break 

10.30            Introduction to hands-on training (module II)

                     Installation of the tools required for the hands-on session on module II

                     M. Battaglini (Italy) - D. Pareto (Spain)

12.30            Homework: Install the required toolboxes (MIPAV, Matlab, SPM, FSL and SCT)                 

13.00            Final wrap-up day 2              

13.15            Closing Lunch


DAY 1 - Tuesday, 7 June 2022 

08.45             Opening and Welcome 

                      N. De Stefano (Italy) - A. Rovira (Spain) 

09.00 L1:       MRI acquisition issues influencing the accuracy of quantitative measurements 

                      M. Battaglini (Italy) - D. Pareto (Spain) 

09.30 L2:       Practical Issues with brain lesions segmentation and brain lesions segmentation

                      M. Battaglini (Italy) - D. Pareto (Spain)

10.00             Q&A

10.15             Coffee break           

10.30             Hands on practice training: brain lesions (lesion load)

                      M. Battaglini (Italy) - D. Pareto (Spain)

                      Learn the Tools: how to use MIPAV to perform manual lesion load

                      • Case 1: T2-W lesion load

                      • Case 2: T1-W lesion load (or black-holes) 

                      • Case 3: Gadolinium enhancing lesion load 

13.00             Lunch

14.00             Hands on practice training: brain lesions (lesion load)

                      M. Battaglini (Italy) - D. Pareto (Spain)

                      How to measure lesion load segmentation with "Lesion Segmentation Toolbox"

16.00 L3:       How to recognize and differentiate spinal cord lesions

                      À. Rovira (Spain)

16.30             Q&A

17.00             End of day 1


DAY 2 - Wednesday, 8 June 2022 

09.00 L4:       Practical issues with global brain volume segmentation

                      N. De Stefano (Italy) 

09.30 L5:       Methods to quantify global brain volumes /changes: pros and limits 

                      M. Battaglini (Italy) - D. Pareto (Spain) 

10.00 L6:       Methods to quantify regional brain volumes: pros and limits

                      M. Battaglini (Italy) - D. Pareto (Spain)

10.30             Q&A

10.45             Coffee break           

11.00             Hands on practice training: brain volume

                      M. Battaglini (Italy) - D. Pareto (Spain)

                      Learn the Tools: how to use SIENAx/SIENA to assess brain volume/change estimation

                      • Cross-sectional cases: SIENAx

                      • Effect of filling on calculated GMF, WMF, BPF

                      • Longitudinal cases: SIENA

13.00             Lunch

14.00             Hands on practice training: Cortical GM volume

                      M. Battaglini (Italy) - D. Pareto (Spain)

                      Introduction to VBM
                      • VBM analysis of grey matter

15.30             Coffee break

15.45             Hands on practice training: deep grey matter volume

                      M. Battaglini (Italy) - D. Pareto (Spain)

                      • FIRST

17.00             Difficulties faced during hand-on sessions

                      (All Faculty Members)

17.30             End of day 2


DAY 3 - Thursday, 9 June 2022 


09.00 L7:       Methods to quantify spinal cord volumes: pros and limits

                      M. Battaglini (Italy) - D. Pareto (Spain)

09.30            Hands on practice training: spinal cord volume

                      M. Battaglini (Italy) - D. Pareto (Spain) 

                      • MIPAV
                      • Spinal cord toolbox

11.30             Coffee break           

11.45             Homework. Attendees will be instructed to perform a real research study based on quantitative assessment of MRI studies (a data set  will be provided)

12.30             Final discussion and wrap-up

12.45             Module II conclusion








Nicola De Stefano









Department of Medicine, Surgery & Neuroscience





University of Siena






Siena, Italy












Alex Rovira









Department of Radiology





Unit of Magnetic Resonance





Vall d’Hebron University Hospital






Barcelona, Spain












Deborah Pareto









Vall d’Hebron University Hospital





Section of Neuroradiology Department of Radiology


















Marco Battaglini









Department of Neurological and Behavioral Sciences





University of Siena






Siena, Italy

















Marco Battaglini









Department of Neurological and Behavioral Sciences





University of Siena






Siena, Italy












Marleen de Bruijne









Erasmus MC





University Medical Centre Rotterdam























Nicola De Stefano









Department of Medicine, Surgery & Neuroscience





University of Siena






Siena, Italy












Deborah Pareto









Vall d’Hebron University Hospital





Section of Neuroradiology Department of Radiology


















Alex Rovira









Department of Radiology





Unit of Magnetic Resonance





Vall d’Hebron University Hospital






Barcelona, Spain












Menno Schoonheim









Department of Anatomy & Neurosciences





VU University Medical Center























  • 17 Feb 2022 until 18 Feb 2022

    International MRIlab Module I - A Journey From The Basics To Advanced Methodologies of MRI

Past Congresses

Ist Congress

September 6, 1969

Colmar, France

Presidents: J.P. Braun & A. Wackenheim


IInd Congress

September 24-25, 1971

London, United Kingdom

President: J.D.W. Bull


IIIrd Congress

August 23-24, 1972 

Bologna, Italy            

President: G. Ruggiero


IVth Congress

September 28-29, 1973

Frankfurt, Germany

President: H. Hacker


Vth Congress

September 4-6, 1975    

Gello, Norway

President: P. Amundsen


VIth Congress

September 16-18, 1976

Dijon, France

President: J. Bories


VIIth Congress

September 9-10, 1977

Barcelona, Spain

President: M. Rovira


VIIIth Congress

September 7-8, 1979

Strasbourg, France                      

President: A. Wackenheim


IXth Congress                  

September 12-13, 1980

Brussels, Belgium

President: G. Cornelis


Xth Congress

September 25-26, 1981

Milan, Italy

President: A. Passerini


XIth Congress

September 15-17, 1983

Bern, Switzerland

President: H. Huber


XIIth Congress

September 27-29, 1984

Prague, former Czechoslovakia

President: J. Jirout



XIIIth Congress

September 11-15, 1985  

Amsterdam, The Netherlands          

President: J. Valk


XIVth Congress

September 8-12, 1987

Udine, Italy

President: M. Leonardi


XVth Congress

September 13-17, 1988    

Wurzburg, Germany

President: M. Nadjmi


XVIth Congress

July 2-6, 1989

Paris, France 

President: E.A. Cabanis


XVIIth  Congress

October 8-13, 1991

Zurich, Switzerland    

President: A. Valavanis


XVIIIth Congress

September 8-12, 1992

Stockholm, Sweden                    

President: K. Ericson


XIXth Congress                  

September 8-12, 1993

Bruges, Belgium

Presidents: B. Appel & D. Balériaux


XXth Congress

June 14-18, 1994

Nancy, France

President: L. Picard



XXIst Congress   

September 20-23, 1995   

Budapest, Hungary         

President: J. Kenéz 


XXIInd Congress

September 17-21, 1996

Milan, Italy

President: G. Scotti



XXIIIrd Congress

September 16-20, 1997   

Oxford, United Kingdom

President: J.V. Byrne


XXIVth Congress 

September 23-26, 1998

Lisbon, Portugal

President: A. Goulão



XXVth Congress

September 7-11, 1999    

Vienna, Austria 

President: E. Schindler


XXVIth Congress  

September 10-13, 2000

Oslo, Norway

President: P.H. Nakstad   


XXVIIth Congress (with ESHNR)

September 13-16, 2001   

Ancona, Italy     

President: U. Salvolini


XXVIIIth Congress

September 11-14, 2003   

Istanbul, Turkey                         

President: E. T. Tali


XXIXth Congress                        

September 8-11, 2004

Aachen, Germany

President: A. Thron


XXXth Congress  

September 15 -18, 2005

Barcelona, Spain

President: J. Ruscalleda


XXXIst Congress

September 13-16, 2006

Geneva, Switzerland

President: D. Rüfenacht