ESNR Advanced Course on Neurodegenerative Diseases

Tuesday 5th November 2019: Cognitive impairment/ dementia

09:00 – 11:00 Session I: Cognitive impairment and dementia: clinical diagnosis and imaging diagnosis in current clinical practice

09:00 – 09:30 The spectrum of cognitive impairment: definition, criteria, various symptom patterns

09:30 – 10:00 Neuropathology of the dementia spectrum

10:00 – 10:30 Imaging in aging: what is normal? (including microbleeds, PVS etc)

10:30 – 11:00 Imaging in cognitive decline: MRI protocols. Why and when which sequences?

11:00 – 11:30 Coffee Break

11:30 – 12:00 Dementia: the differentials (FTD patterns, CBD, vascular dementia)

12:00 – 13:30 Session II: Cognitive impairment and dementia: new imaging biomarkers

12:00 – 12:30 Indications for PET and tracer development in neurodegeneration

12:30 – 13:00 ASL in dementia imaging

13:00 – 13:30 Beyond the minimal MRI protocol: which advanced sequences will change clinical practice? Critical evaluation on the current evidence for clinical application of various advanced MRI techniques, e.g. fMRI, DTI, ASL, and what future implementations will be

13:30 – 14: 30 Lunch

Workshops

14:30 – 16:00 Workshops (40 min per workshop, 5 minutes changing time)

16:00 – 16:30 Coffee Break

16:30 – 18:00 Workshops (40 min per workshop, 5 minutes changing time)

MRI-volumetry: hands on session

PET: case interpretation (FDG, neurotransmission)

Dementia: the differentials (a case-based session)

Integrating Clinical Presentation, MR, PET and CSF

Wednesday 6th November 2019 - Cognitive impairment/ dementia

9:00-11:00 Session I: Cognitive impairment and dementia: prevention, therapy and clinical trials

9:00-9:30 Small vessel diseases

9:30-10:00 Isolated versus mixed pathology: the tale of vascular and amyloid

10:00-10:30 Current Prevention and therapeutic approaches

10:30-11:00 Semi-quantitative rating scales: what is the evidence, and (when) will they be replaced by volumetry?

11:00-11:30 Coffee Break

11:30-12:00 Role of imaging biomarkers in clinical trials (ATN etc): hippocampus, volumetry, ARIA, etc.

12:00-13:30 Session II: Cognitive impairment and dementia: what is on the horizon?

12:00-12:30 Role of ASL versus FDG in dementia: what to choose when?

12:30-13:00 Differences in Tau pathology between AD and FTD: novel genetic insights

13:00-13:30 Role of imaging in disease staging and progression

13:30-14:30 Lunch

14:30 – 16:00 Workshops (40 min per workshop, 5 minutes changing time)

16:00 – 16:30 Coffee Break

16:30 – 18:00 Workshops (40 min per workshop, 5 minutes changing time)

MRI-visual rating scales: a hands-on session

ASL: (hands-on) interpretation and pitfalls

PET: case interpretation (amyloid, tau)

White matter diseases that cause dementia (CSF1R mutations, autoimmune encephalitis, MS): a case-based interactive session

Thursday 7th November, 2019: Movement disorders / Parkinsonism

9:00 11:00 Session I: Movement disorders and Parkinsonism: clinical diagnosis and imaging diagnosis in current clinical practice

9:00 – 9:30 The spectrum of movement disorders (hypokinetic versus hyperkinetic): definition, criteria, various symptom patterns

9:30 – 10:00 Neuropathology of Parkinson’s disease and related disorders

10:00 – 10:30 Imaging in Parkinson’s disease

10:30 – 11:00 Imaging in atypical parkinsonism: MRI protocols. Why and when which sequences?

11:00 11:30 Coffee Break

11:30 – 13:30 Session II: Movement disorders and Parkinsonism: new imaging biomarkers and therapeutic approaches

11:30 – 12:00 Indications for PET and tracer development in Parkinsonism

12:00 – 12:30 Neuromelanin imaging

12:30 – 13:00 PET-MRI in Parkinsonism

13:00 – 13:30 Deep Brain stimulation: neuroanatomy and radiological perspective

13:30 – 14:30 Lunch

14:30 - 15:00 Deep Brain stimulation and focused ultrasound in movement disorders the neurosurgical perspective

15:00 – 16:30 Workshops (40 min per workshop, 5 minutes changing time)

16:30 – 17:00 Coffee Break

17:00 – 18:30 Workshops (40 min per workshop, 5 minutes changing time)

MRI-substantia nigra imaging: a hands-on session

MRI-atypical parkinsonism: a hands on session

PET: case interpretation in movement disorders (FDG, neurotransmission)

Workshop on DBS (case-based)

Friday 8th November, 2019: Dementia and movement disorders: the rarities

9:00-11:00 Session I: The rarities

9:00 -9:30 Huntington’s disease Pathophysiology and Imaging biomarkers, First treatment approaches

9:30 -10:00 Spinocerebellar ataxia

10:00 -10:30 Amyotrophic lateral sclerosis

10:30 -11:00 Neurodegeneration with brain iron accumulation – NBIA

11:00-11:30 Coffee Break

11:30-12:00 Prion diseases

12:00-12:30 Imaging Dementia in Europe: Results of an ESNR Survey

12:30 -13:00 Round Table Discussion